Margaret R MacLean Selected Research

Right Ventricular Hypertrophy

6/2021	Sex-dependent right ventricular hypertrophic gene changes after methamphetamine treatment in mice.
1/2016	Metformin Reverses Development of Pulmonary Hypertension via Aromatase Inhibition.
7/2012	A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples.
2/2010	In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension.
1/2007	Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension.
3/2006	Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice.
5/2004	Overexpression of the 5-hydroxytryptamine transporter gene: effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension.
2/2002	Pulmonary hypertension secondary to left ventricular dysfunction: the role of nitric oxide and endothelin-1 in the control of pulmonary vascular tone.

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Margaret R MacLean Research Topics

Disease

28	Pulmonary Arterial Hypertension 06/2021 - 03/2006
27	Pulmonary Hypertension 11/2020 - 02/2002
16	Hypoxia (Hypoxemia) 04/2020 - 12/2002
10	Vascular Remodeling 12/2020 - 05/2004
8	Right Ventricular Hypertrophy 06/2021 - 02/2002
3	Familial Primary Pulmonary Hypertension 01/2021 - 01/2007
3	Left Ventricular Dysfunction 05/2006 - 02/2002
2	Vascular Diseases (Vascular Disease) 01/2021 - 08/2005
2	Neoplasms (Cancer) 01/2021 - 03/2012
2	Obesity 01/2021 - 07/2020
2	Fibrosis (Cirrhosis) 10/2020 - 01/2013
2	Inflammation (Inflammations) 07/2020 - 03/2012
2	Vascular System Injuries 01/2017 - 03/2012
1	Hypertension (High Blood Pressure) 01/2021
1	Liver Diseases (Liver Disease) 01/2021
1	Hypertrophy 10/2020
1	Carcinoma (Carcinomatosis) 06/2020
1	Heart Diseases (Heart Disease) 03/2012

Drug/Important Bio-Agent (IBA)

15	Serotonin (5 Hydroxytryptamine)IBA 01/2021 - 05/2004
12	Estrogens (Estrogen)FDA Link 01/2021 - 08/2012
10	MicroRNAs (MicroRNA)IBA 01/2021 - 04/2010
6	Proteins (Proteins, Gene)FDA Link 12/2020 - 12/2002
6	Semaxinib (SU5416)IBA 04/2020 - 01/2013
6	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA 01/2017 - 08/2005
4	Type II Bone Morphogenetic Protein Receptors (Bone Morphogenetic Protein Receptor Type II)IBA 01/2021 - 03/2006
4	Aromatase (CYP19)IBA 01/2021 - 08/2014
3	Serotonin ReceptorsIBA 06/2020 - 05/2005
3	Estradiol (Delestrogen)FDA LinkGeneric 01/2020 - 05/2011
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019 - 01/2016
3	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2019 - 08/2012
3	5-HT1B Serotonin ReceptorIBA 01/2017 - 08/2005
3	Messenger RNA (mRNA)IBA 05/2004 - 12/2002
2	salicylhydroxamic acid (SHAM)IBA 10/2020 - 02/2002
2	LeptinIBA 07/2020 - 01/2019
2	Mitogen-Activated Protein KinasesIBA 04/2020 - 04/2003
2	Anastrozole (Arimidex)FDA LinkGeneric 01/2019 - 01/2016
2	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 06/2015 - 03/2006
2	Dexfenfluramine (Redux)IBA 07/2013 - 06/2008
2	EnzymesIBA 07/2013 - 08/2012
2	Tryptophan HydroxylaseIBA 01/2013 - 01/2007
2	Endothelin-1 (Endothelin 1)IBA 07/2006 - 02/2002
2	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 07/2006 - 12/2002
2	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 04/2003 - 12/2002
1	Brain Natriuretic Peptide (Natrecor)FDA Link 06/2021
1	Methamphetamine (Desoxyn)FDA LinkGeneric 06/2021
1	Cytochrome P450 Family 19IBA 01/2021
1	Hormones (Hormone)IBA 01/2021
1	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2021
1	MelatoninIBA 11/2020
1	Collagen Type I (Type I Collagen)IBA 10/2020
1	Natriuretic PeptidesIBA 10/2020
1	Atrial Natriuretic Factor (ANF)IBA 10/2020
1	SteroidsIBA 07/2020
1	AdiponectinIBA 07/2020
1	MAP Kinase Kinase Kinase 5IBA 04/2020
1	CytokinesIBA 04/2020
1	Fulvestrant (Faslodex)FDA Link 11/2019
1	Therapeutic UsesIBA 01/2019
1	2,2',4,6'-tetramethoxystilbeneIBA 01/2019
1	2-MethoxyestradiolIBA 01/2019
1	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 01/2018
1	Cytochrome P-450 CYP1A1 (CYP1A1)IBA 01/2018
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2018
1	NADPH Oxidase 1IBA 01/2017
1	AntioxidantsIBA 01/2017
1	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2017
1	Oxidoreductases (Dehydrogenase)IBA 01/2016
1	AMP-Activated Protein KinasesIBA 01/2016
1	NADP (NADPH)IBA 01/2016
1	Metformin (Glucophage)FDA LinkGeneric 01/2016
1	Transforming Growth Factors (Transforming Growth Factor)IBA 10/2015
1	Estrogen ReceptorsIBA 10/2015
1	hexachlorocyclohexane x-factorIBA 10/2015
1	hydralazine 4-anisaldehyde hydrazoneIBA 03/2015
1	Caspase 3 (Caspase-3)IBA 07/2014
1	Imatinib Mesylate (Gleevec)FDA Link 01/2013
1	CollagenIBA 01/2013
1	AntagomirsIBA 07/2012
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 04/2010
1	MonocrotalineIBA 04/2010
1	Citalopram FDA LinkGeneric 02/2010
1	LY 393558IBA 02/2010
1	p38 Mitogen-Activated Protein KinasesIBA 06/2008
1	AminorexIBA 06/2008
1	Protein Isoforms (Isoforms)IBA 07/2006
1	Indomethacin (Indometacin)FDA LinkGeneric 07/2006
1	Adenylyl Cyclases (Adenylyl Cyclase)IBA 07/2006
1	MitogensIBA 07/2006
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 07/2006
1	Cyclooxygenase InhibitorsIBA 07/2006
1	U 0126 (UO 126)IBA 07/2006
1	Type 4 Cyclic Nucleotide PhosphodiesterasesIBA 07/2006
1	Phospholipases (Phospholipase)IBA 07/2006
1	Prostaglandins EIBA 07/2006
1	urotensin IIIBA 05/2006

Therapy/Procedure

2	Therapeutics 12/2020 - 06/2020
2	Ovariectomy (Oophorectomy) 03/2015 - 05/2011
2	Ligation 05/2006 - 02/2002
1	Subcutaneous Injections 04/2020
1	Stents 03/2012